Useful Links & Tools
- MSDS
- Certificate of Analysis
- Antibiotics biofiles4 (2 MB )
- Antibiotics biofiles4 (2 MB )
- Bulk Quote
- Similar Products
C5241
Sigma
Cinnamycin
>95% (HPLC), solid
| Synonym: | Ro 09-0198 |
| Amino Acid Sequence: | Cys-Arg-Gln-Cys-Cys--3-NH2-Ala-Phe-Gly-Pro-Phe-(2S,3S)-2-amino-3-mercaptobutanoyl-Phe-Val-Cys-3-OH-α-Asp-Gly-Asn-(2S,3S)-2-amino-3-mercaptobutanoyl-Lys Disulfide bridges: 1-18, 4-14, 5-11; Lysinoalanine bridge: 6-19 |
| CAS Number: | 110655-58-8 |
| Linear Formula: | C89H125N25O25S3 |
| Molecular Weight: | 2041.29 |
| MDL number: | MFCD01770867 |
Description
| Biochem/physiol Actions | Cinnamycin (Ro 09-0198) is a tetracylic peptide antibiotic (19 amino acids) that binds specifically to the cell surface phosphatidylethanolamine and subsequently induces cytolysis. This is a rare example of a small peptide binding to a particular lipid (1:1 complex). Cinnamycin belongs to the duramycin-type lantibiotics and contains the unusual thioether lanthionine amino acids. |
| General description | Useful tool for monitoring transbilayer movement of PE in membranes, and studying the functional role of PE in cytokinesis, membrane protein folding, and apoptosis. |
Properties
| assay | >95% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | acetonitrile: water (1:1): ≥5 mg/mL |
| methanol: water (1:1): ≥5 mg/mL | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | GE1745000 |
References
| reference | Machiadze, G., et al., Specific binding of Ro 09-0198 (cinnamycin) to phosphatidylethanolamine: a thermodynamic analysis. Biochemistry 41, 1965-1971, (2002) |
| Widdick, D. A. et al., Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005 Proc. Natl. Acad. Sci. U. S. A. 100, 4316-4321, (2003) |
